Top^Fine Chemicals Division^Product Information^Highly Purified Phospholipids ˆê‚ã‚Ö Next

Product Information

 Highly Purified Phospholipids

Highly purified and thus stabilized phospholipids have been prepared based on our own developed technologies. They are used as the key materials for liposomal drugs, lung surfactants, and excipients or modifier of drugs and getting market confidence.

All phospholipids for pharmaceutical use are manufactured under the compliance of GMP requirements.

During these activities, NFC got the academic award titled gSyntheses of highly purified phospholipids and their sophisticated applicationsh from Japan Oil Chemists Society in 1997.

PhosphoLipid@DAPC

This type of compound is synthesized by converting a natural PC into an acyl group through a chemical reaction.

Product name IUPAC name Generic name Cas Reg. No. Fatty acid constitution Purity * Appearance
PhosphoLipid-DPPC 1,2-Dipalmitoyl-sn-glycero-3-phosphocholine Dipalmitoyl phosphatidylcholine 63-89-8, Palmitic acid 99% or higher White powder
PhosphoLipid-DSPC 1,2-Distearoyl-sn-glycero-3-phosphocholine Distearoyl phosphatidylcholine 816-94-4 Stearic acid 99% or higher White powder
PhosphoLipid-DMPC 1,2-Dimyristoyl-sn-glycero-3-phosphocholine Dimyristoyl phosphatidylcholine 18194-24-6 Myristic acid 99% or higher White powder
PhosphoLipid-DLPC 1,2-Dilinoleoyl-sn-glycero-3-phosphocholine Dilinoleoyl phosphatidylcholine 998-06-1 Linoleic acid 99% or higher Pale yellow powder
PhosphoLipid-DLAPC 1,2-Dilauroyl-sn-glycero-3-phosphocholine Dilauroyl phosphatidylcholine 18194-25-7 Lauric acid 99% or higher White solid
PhosphoLipid-DOPC 1,2-Dioleoyl-sn-glycero-3-phosphocholine Dioleoyl phosphatidylcholine 4235-95-4 Oleic acid 99% or higher White solid
PhosphoLipid-DEPC 1,2-Dielaidoyl-sn-glycero-3-phosphocholine Dielaidoyl phosphatidylcholine 56782-46-8 Elaidic acid 99% or higher White powder
PhosphoLipid-DERPC 1,2-Dierucoyl-sn-Glycero-3-Phosphocholine Dierucoyl phosphatidylcholine 51779-95-4 Ericic scid 99% or higher White powder
* HPLC area purity

PhosphoLipid@PC

This line of products is obtained by hydrogenating an unsaturated bond of a highly purified natural PC (Phosphatidychloline) and an acyl group.

Product name IUPAC name Generic name Cas Reg. No. Fatty acid constitution Purity * Appearance
PhosphoLipid-PCE 1,2-Diacyl-sn-Glycero-3-Phosphocholine (EGG) Phosphatidylcholine (EGG) 8002-43-5 Mixture 95% or higher Pale yellow solid
PhosphoLipid-PCEH 1,2-Diacyl-sn-Glycero-3-Phosphocholine (EGG) Phosphatidylcholine Hydrogenated (EGG) 8002-43-5, Mixture 95% or higher White powder
PhosphoLipid-PCS 1,2-Diacyl-sn-Glycero-3-Phosphocholine (SOY) Phosphatidylcholine@(SOY) 8002-43-5 Mixture 95% or higher Pale yellow solid
PhosphoLipid-PCSH 1,2-Diacyl-sn-Glycero-3-Phosphocholine (SOY) Phosphatidylcholine Hydrogenated@(SOY) 8002-43-5 Mixture 95% or higher White powder
* HPLC area purity

PhosphoLipid@PG and PA

PG (Pohsphatidyglycerol) and PA (Phosphatidic acid) appear to be the next promising materials following PC (Phosphatidychloline).

Both materials appear to be promising, not only as the ingredients for generating liposomes but also as raw materials for pharmaceutical and cosmetic ingredients, because of their unique surface activity and bioactivity.

Nippon Fine Chemical, knowledgeable about the unique functions of PG and PA, has promptly established production processes for these materials.

Product name IUPAC name Generic name Cas Reg. No. Fatty acid constitution Purity * Appearance
PhosphoLipid-DPPG 1,2-Dipalmitoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt) Dipalmitoyl phosphatidylglycerol 67232-81-9 Palmitic acid 99% or higher White powder
PhosphoLipid-DMPG 1,2-Dimyristoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt) Dimyristoyl phosphatidylglycerol 67232-80-8 Myristic acid 99% or higher White powder
PhosphoLipid-DSPG 1,2-Distearoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt) Distearoyl phosphatidylglycerol 4537-78-4 Stearic acid 99% or higher White powder
PhosphoLipid-DOPG 1,2-Dioleoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt) Dioleoyl phosphatidylglycerol 62700-69-0 Oleic acid 99% or higher White solid
PhosphoLipid-PGE 1,2-Diacyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt, EGG) Phosphatidylglycerol (EGG) N/A Mixture 95% or higher Pale yellow solid
PhosphoLipid-PGEH 1,2-Diacyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt, EGG) Phosphatidylglycerol Hydrogenated (EGG) N/A Mixture 97% or higher White powder
PhosphoLipid-PGS 1,2-Diacyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt, SOY) Phosphatidylglycerol (SOY) N/A Mixture 95% or higher Pale yellow solid
PhosphoLipid-PGSH 1,2-Diacyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt, SOY) Phosphatidylglycerol Hydrogenated (SOY) N/A Mixture 97% or higher White powder
PhosphoLipid-DPPA 1,2-Dipalmitoyl-sn-Glycero-3-Phosphate(Sodium Salt) Dipalmitoyl phosphatidic acid 71065-87-7 Palmitic acid 97% or higher White powder
PhosphoLipid-DMPA 1,2-Dimyristoyl-sn-Glycero-3-Phosphate(Sodium Salt) Dimyristoyl phosphatidic acid 80724-31-8 Myristic acid 97% or higher White powder
PhosphoLipid-PAE 1,2-Diacyl-sn-Glycero-3-Phosphate(Sodium Salt, EGG) Phosphatidic acid (EGG) N/A Mixture 97% or higher Pale yellow solid
* HPLC area purity

PhosphoLipid@POPC, POPG, DPDG

With many phospholipids in human cells, the 1-position of glycerol has a bond with saturated fatty acid while the 2-position of glycerol has a bond with unsaturated fatty acid.

Recently, demand is increasing for glycerols that have more natural structures. In response, Nippon Fine Chemical offers the following products that are formulated through advanced enzyme reactions.

Product name IUPAC name Generic name Cas Reg. No. Fatty acid constitution Purity * Appearance
PhosphoLipid-POPC 2-Oleoyl-1-palmitoyl-sn-glycero-3-phosphocholine 1-Palmitoyl 2-Oleoyl phosphatidylcholine 26853-31-6 Palmitic acid
Oleic‚cid
99% or higher White powder
PhosphoLipid-POPG 1-Palmitoyl-2-Oleoyl-sn-Glycero-3-[Phospho-rac-(1-glycerol)] (Sodium Salt) 1-Palmitoyl 2-Oleoyl phosphatidylglycerol 81490-05-3 Palmitic acid
Oleic‚cid
99% or higher White powder
PhosphoLipid-DPDG 1,2-Dipalmitoyl-sn-Glycerol 1,2Dialmitoyl Diglycerid 67232-81-9 Palmitic acid 97% or higher White powder
* HPLC area purity

PhosphoLipid@LPC

Lisophospholipid (LPC) obtained from PC (Phosphatidylcholine) hydrolyzed by enzyme phosphplipase shows the excellent characteristic of hydrophilic emulsifier.

They are lisophospholipid with highly purified acyl group.

Product name IUPAC name Generic name Cas Reg. No. Fatty acid constitution Purity * Appearance
LysoPhosphoLipid 1-Ste lysoPC 1-Stearoyl-sn-glycero-3-phosphocholine 1-Stearoyl-lysophosphatidylcholine 19420-57-6 Stearic acid 98% or higher White powder
LysoPhosphoLipid 1-Pal lysoPC 1-Palmitoyl-sn-glycero-3-phosphocholine 1-Palmitoy-lysophosphatidylcholine 17364-16-8 Palmitic acid 98% or higher White powder
* HPLC area purity

Presome

The Presomes are lipid mixtures for preparing liposomes.

Use of a Presome will eliminate a complicated procedure for preparing a liposome. A user only needs to add an aqueous solution and initiate a decomposition process in order to obtain a liposome solution.

This technology has been patented not only in Japan but also in America and Europe.

Product name Phospholipid acid composition Molar ratio
Presome EEG-‡T PCE : Cho : PGE 1 : 1 : 0.2
Presome MMG-‡U DMPC: Cho : DMPG 1 : 0.5 : 0.15
Presome PPG-‡T DPPC : Cho : DPPG 1 : 1 : 0.2
Presome PGA-‡T CPPC : Cho : PGA 1 : 1 : 0.25
 (Contact)
Lipid Department : lipid@nipponseika.com